Description

(4-Chloro-3-Trifluoromethyl-Phenyl)-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting specific therapeutic areas. It is essential for research and development laboratories, process chemists, and manufacturers in the global pharmaceutical and agrochemical industries who require reliable, high-quality intermediates for scalable production.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the trifluoromethyl group for enhanced biological activity.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Development: Employed in pilot plant and scale-up activities to establish robust and efficient synthetic routes for target molecules.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.

Basic Information

Product Name	(4-Chloro-3-Trifluoromethyl-Phenyl)-Carbamic Acid tert-Butyl Ester
CAS No.	352277-93-1
Molecular Formula	C12H13ClF3NO2
Molecular Weight	295.69 g/mol
Synonyms	tert-Butyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate; N-Boc-4-chloro-3-(trifluoromethyl)aniline; 1-(tert-Butoxycarbonylamino)-4-chloro-3-(trifluoromethyl)benzene; 4-Chloro-3-trifluoromethylphenylcarbamic Acid tert-Butyl Ester; BOC-4-Chloro-3-trifluoromethylaniline; N-(tert-Butoxycarbonyl)-4-chloro-3-(trifluoromethyl)aniline; (4-Chloro-3-trifluoromethylphenyl)carbamic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (4-Chloro-3-Trifluoromethyl-Phenyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.