Description

tert-Butyl n-({5-Azaspiro[2.4]Heptan-7-Yl}Methyl)Carbamate is a specialized, high-purity organic building block featuring a unique spirocyclic amine structure protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry and pharmaceutical research, serving as a versatile intermediate in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce constrained, nitrogen-containing scaffolds into their molecular designs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its spirocyclic scaffold which can improve metabolic stability and binding affinity.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) by introducing a rigid, three-dimensional amine component.
• Protease Inhibitor Development: Serves as a precursor for compounds designed to inhibit specific enzymes, such as proteases, where the spiro[2.4]heptane core can mimic transition states.
• Agrochemical Synthesis: Employed in the research and development of new herbicides or pesticides that require sophisticated nitrogen heterocycles for enhanced activity and selectivity.
• Peptidomimetics: The Boc-protected amine is a valuable synthon for creating peptidomimetics, where the spirocyclic structure replaces traditional amino acids to confer resistance to enzymatic degradation.
• Ligand and Catalyst Preparation: Can be utilized to develop novel chiral ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	tert-Butyl n-({5-Azaspiro[2.4]Heptan-7-Yl}Methyl)Carbamate
CAS No.	351369-07-8
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	7-[(tert-Butoxycarbonylamino)methyl]-5-azaspiro[2.4]heptane; tert-Butyl N-[(5-azaspiro[2.4]heptan-7-yl)methyl]carbamate; Boc-5-azaspiro[2.4]heptane-7-methanamine; (5-Azaspiro[2.4]heptan-7-ylmethyl)-carbamic acid tert-butyl ester; tert-Butyl (5-azaspiro[2.4]heptan-7-ylmethyl)carbamate; 351369-07-8; Boc-Azaspiroheptylmethylamine
EINECS	Contact for details

Quality Control

Our tert-Butyl n-({5-Azaspiro[2.4]Heptan-7-Yl}Methyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP (current Good Manufacturing Practice) compliance for use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.