Description

5-Bromo-2,4-Difluoro-Benzoic Acid Methyl Ester is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its role in introducing halogen and fluorine substituents into complex molecular architectures, enabling precise modifications to chemical and physical properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing halogenated difluorophenyl motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the bromo-difluoro benzoate structure confers specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating specialized chemical libraries.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and material chemistry.

Basic Information

Product Name	5-Bromo-2,4-Difluoro-Benzoic Acid Methyl Ester
CAS No.	351325-31-0
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	Methyl 5-Bromo-2,4-difluorobenzoate; 5-Bromo-2,4-difluorobenzoic Acid Methyl Ester; Benzoic acid, 5-bromo-2,4-difluoro-, methyl ester; 2,4-Difluoro-5-bromobenzoic Acid Methyl Ester; Methyl 5-Bromo-2,4-difluorobenzoate; 351325-31-0; Methyl 2,4-Difluoro-5-bromobenzoate
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,4-Difluoro-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.