Description

4-Fluoro-3-Methylphenyl Isocyanate is a high-purity aromatic isocyanate derivative, a crucial building block in advanced organic synthesis. Its primary value lies in its reactivity as an electrophile, enabling the efficient introduction of the 4-fluoro-3-methylphenyl carbamoyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and fine chemical intermediates where specific fluorine-substituted aromatic structures are required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in areas like kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialty polyurethanes and polyurea coatings with tailored properties.
• Ligand and Material Science: Employed in the synthesis of specialized ligands for catalysis and in the creation of advanced organic materials.
• Custom Synthesis & Research: A vital reagent for contract research organizations (CROs) and academic labs exploring new chemical entities and reaction pathways.

Basic Information

Item	Detail
Product Name	4-Fluoro-3-Methylphenyl Isocyanate
CAS No.	351003-65-1
Molecular Formula	C8H6FNO
Molecular Weight	151.14 g/mol
Synonyms	3-Methyl-4-fluorophenyl isocyanate; 4-Fluoro-m-tolyl isocyanate; 1-Isocyanato-4-fluoro-3-methylbenzene; (4-Fluoro-3-methylphenyl)carbimidoic acid; NSC 405124; 4-Fluoro-3-methylbenzenisocyanate; Isocyanic acid, 4-fluoro-3-methylphenyl ester
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methylphenyl Isocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure a typical purity of ≥98% and conformity to specified impurity profiles. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.