Description

tert-Butyl 4-Bromo-3-Methylbenzoate is a high-purity organic building block and ester derivative of benzoic acid. This compound is valued for its role as a versatile synthetic intermediate in advanced organic synthesis and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring a substituted benzoate ester moiety.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, leveraging the bromo and methyl substituents for structural diversification.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers where specific aromatic esters are required.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.
• Academic & Industrial R&D: Essential reagent in medicinal chemistry labs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	tert-Butyl 4-Bromo-3-Methylbenzoate
CAS No.	347174-28-1
Molecular Formula	C12H15BrO2
Molecular Weight	271.15 g/mol
Synonyms	4-Bromo-3-methylbenzoic acid tert-butyl ester; Benzoic acid, 4-bromo-3-methyl-, 1,1-dimethylethyl ester; tert-Butyl 4-bromo-3-methylbenzoate; 1,1-Dimethylethyl 4-bromo-3-methylbenzoate; 4-Bromo-3-methyl-benzoic acid tert-butyl ester; 3-Methyl-4-bromobenzoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Bromo-3-Methylbenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.