Description

1'H-Spiro[Cyclopentane-1,2'-Quinazoline]-4'-Thiol is a high-purity, specialized heterocyclic organic compound featuring a unique spirocyclic quinazoline-thiol structure. This compound is valued as a critical pharmaceutical intermediate and research chemical for the development of novel bioactive molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Development: Acts as a precursor in the research and synthesis of novel pesticides and herbicides.
• Chemical Biology Probe: Utilized in biochemical research to study enzyme inhibition or protein interactions due to its reactive thiol group.
• Material Science Research: Investigated as a monomer or ligand precursor for advanced polymeric materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	1'H-Spiro[Cyclopentane-1,2'-Quinazoline]-4'-Thiol
CAS No.	346458-41-1
Molecular Formula	C12H14N2S
Molecular Weight	218.32 g/mol
Synonyms	4'-Mercapto-1'H-spiro[cyclopentane-1,2'-quinazoline]; Spiro[cyclopentane-1,2'-quinazoline]-4'-thiol; 1'H-Spiro(cyclopentane-1,2'-quinazoline)-4'-thiol; Quinazoline-4'-thiol, 1'H-spiro[cyclopentane-1,2']-; 346458-41-1; 4'-Thio-1'H-spiro[cyclopentane-1,2'-quinazoline]
EINECS	Contact for details

Quality Control

Our 1'H-Spiro[Cyclopentane-1,2'-Quinazoline]-4'-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be kept sealed and only opened in an inert environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.