Description

6-Fluoro-1,2-Dihydro-2-Oxospiro[4H-3,1-Benzoxazine-4,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethyl Ethyl Ester is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and benzoxazine scaffold. This compound is critical for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is primarily sought by research institutions, custom synthesis houses, and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of proprietary drug candidates, especially those targeting neurological disorders.
• Drug Discovery & Medicinal Chemistry: Used as a versatile scaffold for constructing compound libraries to explore structure-activity relationships (SAR) and identify new lead molecules.
• Process Research & Development (PR&D): Employed in route scouting, optimization, and scale-up studies for the commercial manufacturing of target APIs.
• Reference Standard: Utilized as an analytical standard for quality control and method validation during API production.
• Custom Synthesis & Contract Manufacturing: A key material for fine chemical suppliers offering bespoke synthesis services to the pharmaceutical industry.

Basic Information

Product Name	6-Fluoro-1,2-Dihydro-2-Oxospiro[4H-3,1-Benzoxazine-4,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethyl Ethyl Ester
CAS No.	345938-08-1
Molecular Formula	C18H21FN2O4
Molecular Weight	348.37 g/mol
Synonyms	6-Fluoro-1,2-dihydro-2-oxospiro[4H-3,1-benzoxazine-4,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 6-fluoro-2-oxo-1,2-dihydrospiro[4H-3,1-benzoxazine-4,4'-piperidine]-1'-carboxylate; Spiro[4H-3,1-benzoxazine-4,4'-piperidine]-1'-carboxylic acid, 6-fluoro-1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester; Boc-protected 6-fluoro spirocyclic benzoxazinone piperidine; 6-Fluoro spiro(benzoxazine-4,4'-piperidine) tert-butyl carbamate derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support compliance with cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.