Description

4-Hydroxy-2-Methylsulfanyl-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidine-6-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in the synthesis of complex molecules, offering a versatile scaffold for medicinal chemistry and drug discovery programs. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers targeting the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Chemical Synthesis Building Block: Employed in the construction of complex heterocyclic compounds and fused pyrimidine derivatives.
• Biochemical Research: Potential use as a tool compound or reference standard in biochemical and pharmacological assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-Hydroxy-2-Methylsulfanyl-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidine-6-Carboxylic Acid tert-Butyl Ester
CAS No.	344958-26-5
Molecular Formula	C14H19N3O3S
Molecular Weight	309.38 g/mol
Synonyms	tert-Butyl 4-hydroxy-2-(methylthio)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate; 4-Hydroxy-2-(methylthio)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester; 2-(Methylthio)-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid tert-butyl ester; Pyrido[4,3-d]pyrimidine-6-carboxylic acid derivative; CAS 344958-26-5
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2-Methylsulfanyl-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidine-6-Carboxylic Acid tert-Butyl Ester is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.