Description

3 6-Di-o-(tert-Butyldiphenylsilyl)-D- is a high-purity, protected carbohydrate derivative, specifically a silyl ether-protected sugar intermediate, with the CAS number 344303-60-2. This compound is a critical building block in synthetic organic chemistry, valued for its role in introducing stereochemical control and protecting sensitive hydroxyl groups during complex multi-step syntheses. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of nucleoside analogs, antiviral agents, and other sophisticated bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Oligonucleotide Synthesis: Used in the preparation of protected phosphoramidite monomers for solid-phase synthesis of DNA/RNA analogs.
• Glycochemistry Research: Serves as a crucial intermediate for constructing complex carbohydrate structures and glycoconjugates.
• Process Chemistry: Employed in scale-up routes for active pharmaceutical ingredients (APIs) requiring specific sugar modifications.
• Chemical Biology Probes: Utilized to create labeled or modified sugar derivatives for studying biological recognition and metabolic pathways.
• Academic & Industrial R&D: A valuable reagent for methodological development in asymmetric synthesis and protective group chemistry.

Basic Information

Product Name	3 6-Di-o-(tert-Butyldiphenylsilyl)-D-
CAS No.	344303-60-2
Molecular Formula	C38H48O5Si2
Molecular Weight	641.0 g/mol
Synonyms	1,2:5,6-Di-O-(tert-Butyldiphenylsilyl)-α-D-glucofuranose; 3,6-Di-O-(tert-Butyldiphenylsilyl)-D-glucofuranose; 1,2:5,6-Di-O-(TBDPS)-α-D-glucofuranose; D-Glucofuranose, 1,2:5,6-bis-O-[(1,1-dimethylethyl)diphenylsilyl]-; TBDPS-protected D-glucofuranose derivative; 344303-60-2; tert-Butyldiphenylsilyl protected sugar
EINECS	Contact for details

Quality Control

Our 3 6-Di-o-(tert-Butyldiphenylsilyl)-D- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, with specifications tailored to meet the rigorous requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.