Description

2-Amino-4-(2-Chlorophenyl)-5,6-Dimethylnicotinonitrile is a high-value, multi-functional heterocyclic building block with a CAS number of 344264-31-9. This compound is essential for advanced organic synthesis, serving as a critical precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex heterocyclic compounds with potential biological activity, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new generation herbicides, fungicides, and insecticides, leveraging its chlorophenyl and aminonitrile functionalities.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic semiconductors.
• Dye & Pigment Synthesis: Employed in the creation of specialized dyes and pigments due to its conjugated nitrile and aromatic system.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in palladium-catalyzed cross-coupling and cyclization reactions.

Basic Information

Product Name	2-Amino-4-(2-Chlorophenyl)-5,6-Dimethylnicotinonitrile
CAS No.	344264-31-9
Molecular Formula	C14H12ClN3
Molecular Weight	257.72 g/mol
Synonyms	2-Amino-4-(2-chlorophenyl)-5,6-dimethyl-3-pyridinecarbonitrile; 5,6-Dimethyl-2-amino-4-(2-chlorophenyl)nicotinonitrile; 4-(2-Chlorophenyl)-2-amino-5,6-dimethyl-3-cyanopyridine; 2-Amino-4-(o-chlorophenyl)-5,6-dimethylnicotinonitrile; 3-Cyano-2-amino-4-(2-chlorophenyl)-5,6-dimethylpyridine; 344264-31-9; 2-Amino-4-(2-chlorophenyl)-5,6-dimethyl-3-cyanopyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-4-(2-Chlorophenyl)-5,6-Dimethylnicotinonitrile undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocol includes multiple orthogonal methods such as HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.