Description

4-Bromo-o-(T-Butyldimethylsilyl)-2,6-Dichlorophenol is a high-value, multi-functional organosilicon intermediate featuring a sterically hindered phenolic core. This compound is critical for advanced organic synthesis, offering a unique combination of a protected phenol and halogen handles for selective functionalization. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, such as active pharmaceutical ingredients (APIs) and specialty ligands.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the silyl-protected phenol moiety is essential for bioactivity and stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialized polymers and advanced organic materials with tailored properties.
• Catalyst & Ligand Development: Employed in the design and synthesis of novel organometallic catalysts and chiral ligands for asymmetric synthesis.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new coupling reactions and protective group strategies.
• Fine Chemical Production: Integral to the multi-step synthesis of high-value specialty chemicals and flavors & fragrances.

Basic Information

Product Name	4-Bromo-o-(T-Butyldimethylsilyl)-2,6-Dichlorophenol
CAS No.	343564-38-5
Molecular Formula	C₁₂H₁₇BrCl₂OSi
Molecular Weight	380.16 g/mol
Synonyms	4-Bromo-2,6-dichloro-[(1,1-dimethylethyl)dimethylsilyl]oxybenzene; 2,6-Dichloro-4-bromo-[(tert-butyldimethylsilyl)oxy]benzene; 4-Bromo-2,6-dichlorophenol TBDMS ether; 4-Bromo-2,6-dichlorophenyl tert-butyldimethylsilyl ether; TBDMS ether of 4-bromo-2,6-dichlorophenol; 4-Br-2,6-Cl₂-Ph-OTBDMS; CAS 343564-38-5
EINECS	Contact for details

Quality Control

Our 4-Bromo-o-(T-Butyldimethylsilyl)-2,6-Dichlorophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our commitment to traceability and batch-to-batch consistency supports critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.