Description

3-Amino-2-Chloropyridine-4-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant commercial and research interest. This compound matters as a key intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique substitution pattern enables the construction of novel active ingredients. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and advanced material precursors.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its pyridine core.
• Material Science Research: Serves as a precursor for functionalized ligands in catalysis and for creating specialty polymers with tailored properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic & Industrial R&D: A versatile starting material for methodological chemistry development and library synthesis in discovery programs.

Basic Information

Product Name	3-Amino-2-Chloropyridine-4-Carbonitrile
CAS No.	342899-37-0
Molecular Formula	C6H4ClN3
Molecular Weight	153.57 g/mol
Synonyms	2-Chloro-3-aminopyridine-4-carbonitrile; 4-Cyano-2-chloro-3-aminopyridine; 3-Amino-2-chloro-4-cyanopyridine; 2-Chloro-3-amino-4-cyanopyridine; 4-Cyano-2-chloro-3-pyridinamine; 3-Pyridinamine, 2-chloro-4-cyano-; (2-Chloro-4-cyanopyridin-3-yl)amine; 342899-37-0
EINECS	Contact for details

Quality Control

Our 3-Amino-2-Chloropyridine-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ISO, and other relevant quality standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.