Description

1-(Trimethylsilyldifluoromethyl)-2-Methyl-1H-Benzoimidazole is a specialized organosilicon reagent featuring a reactive difluoromethyl group. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly for introducing fluorinated motifs. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its unique structure enables critical transformations in medicinal chemistry and materials science.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides with enhanced properties.
• Fluorination Reagent: Serves as a source of the difluoromethyl (CF2H) group in nucleophilic or radical fluorination reactions.
• Organosilicon Chemistry: Employed in reactions leveraging the trimethylsilyl (TMS) group for protection or as a leaving group.
• Materials Science Research: Used in the development of fluorinated polymers, liquid crystals, and advanced organic electronic materials.
• Cross-Coupling Reactions: Potential precursor for palladium-catalyzed couplings to create complex, fluorinated aromatic systems.

Basic Information

Product Name	1-(Trimethylsilyldifluoromethyl)-2-Methyl-1H-Benzoimidazole
CAS No.	341529-09-7
Molecular Formula	C12H16F2N2Si
Molecular Weight	254.35 g/mol
Synonyms	2-Methyl-1-[(trimethylsilyl)difluoromethyl]-1H-benzimidazole; 1H-Benzimidazole, 1-[(difluoromethyl)trimethylsilyl]-2-methyl-; (Difluoromethyl)trimethylsilyl-2-methylbenzimidazole; 1-(Difluoromethyl)trimethylsilyl-2-methylbenzimidazole; TMS-CF2H-Benzimidazole Reagent; Trimethylsilyldifluoromethyl-2-methylbenzimidazole
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyldifluoromethyl)-2-Methyl-1H-Benzoimidazole is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and identity. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.