Description

2-Phenyl-Imidazol-1-Yl-Difluoromethyl-Trimethylsilane is a specialized organosilicon reagent featuring a reactive difluoromethyl group. This compound matters as a versatile building block for introducing the difluoromethylene (CF2) moiety into target molecules, a critical modification in modern medicinal and agrochemical design. Pharmaceutical researchers and fine chemical manufacturers need it for the synthesis of novel active ingredients, particularly where enhanced metabolic stability and lipophilicity are desired.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates containing difluoromethyl groups, improving their pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides with optimized efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for modifying surfaces or creating novel fluorinated polymers and advanced materials.
• Organic Synthesis Reagent: Acts as a difluoromethylating agent in various transition-metal-catalyzed or radical reactions to construct complex organic frameworks.
• Fluorine Chemistry Studies: Essential for academic and industrial research focused on developing new methodologies for incorporating fluorine atoms into molecules.

Basic Information

Product Name	2-Phenyl-Imidazol-1-Yl-Difluoromethyl-Trimethylsilane
CAS No.	341529-08-6
Molecular Formula	C13H17F2N2Si
Molecular Weight	267.37 g/mol
Synonyms	1-[(Difluoromethyl)trimethylsilyl]-2-phenyl-1H-imidazole; (Difluoromethyl)trimethylsilyl 2-phenylimidazole; 2-Phenyl-1-((trimethylsilyl)difluoromethyl)imidazole; Trimethyl((2-phenyl-1H-imidazol-1-yl)difluoromethyl)silane; TMS-CF2-Imidazole-Phenyl; Difluoromethyl(trimethyl)silyl 2-phenylimidazole; 1H-Imidazole, 1-[(difluoromethyl)trimethylsilyl]-2-phenyl-
EINECS	Contact for details

Quality Control

Our 2-Phenyl-Imidazol-1-Yl-Difluoromethyl-Trimethylsilane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.