Description

2-Amino-5-{3-Bromo-4-[(2-Chlorobenzyl)Oxy]-5-Methoxybenzylidene}-4,6-Dimethyl-5H-Cyclopenta[B]Pyridine-3,7-Dicarbonitrile is a complex, high-value heterocyclic organic compound featuring a cyclopenta[b]pyridine core with multiple functional groups, including amino, cyano, and halogenated benzylidene substituents. This structural complexity makes it a critical advanced pharmaceutical intermediate for the research and development of novel therapeutic agents, particularly in oncology and targeted drug discovery. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in synthesizing potent, selective small-molecule inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Chemical Biology Research: Used as a molecular probe or scaffold in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Organic Synthesis: Acts as a versatile precursor for further functionalization, leveraging its reactive amino and cyano groups for constructing more complex heterocyclic systems.
• Material Science Research: Potential application in developing organic semiconductors or luminescent materials due to its extended conjugated π-system.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.

Basic Information

Product Name	2-Amino-5-{3-Bromo-4-[(2-Chlorobenzyl)Oxy]-5-Methoxybenzylidene}-4,6-Dimethyl-5H-Cyclopenta[B]Pyridine-3,7-Dicarbonitrile
CAS No.	340228-14-0
Molecular Formula	C26H20BrClN4O2
Molecular Weight	543.82 g/mol
Synonyms	2-Amino-5-(3-bromo-4-((2-chlorobenzyl)oxy)-5-methoxybenzylidene)-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile; 5H-Cyclopenta[b]pyridine-3,7-dicarbonitrile, 2-amino-5-[3-bromo-4-[(2-chlorophenyl)methoxy]-5-methoxyphenyl]methylene]-4,6-dimethyl-; CAS 340228-14-0; Cyclopenta[b]pyridine derivative 340228-14-0; 2-Amino-5-(3-bromo-4-(2-chlorobenzyloxy)-5-methoxybenzylidene)-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile
EINECS	Contact for details

Quality Control

Every batch of this high-purity intermediate is manufactured under cGMP-compliant conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and results from all specified tests is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.