Description

1-(2-Chloro-6-Fluorobenzyl)-5-Cyano-6-Methyl-1,2,3,4-Tetrahydropyridin-2-One is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 338748-74-6. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is essential for medicinal chemistry research, process development, and scale-up manufacturing within the pharmaceutical and biotechnology industries.

Application

This specialized intermediate serves as a key precursor in several high-value synthetic pathways.

• Pharmaceutical Intermediate: Primary use in the research and development of novel drug candidates, especially for neurological targets.
• Medicinal Chemistry Research: A versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Used in route development and pilot-scale synthesis for new chemical entities (NCEs).
• Contract Manufacturing (CMO): Supplied to CMOs for the cGMP production of clinical trial materials and commercial APIs.
• Reference Standard: Serves as an analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	1-(2-Chloro-6-Fluorobenzyl)-5-Cyano-6-Methyl-1,2,3,4-Tetrahydropyridin-2-One
CAS No.	338748-74-6
Molecular Formula	C14H12ClFN2O
Molecular Weight	278.71 g/mol
Synonyms	1-[(2-Chloro-6-fluorophenyl)methyl]-5-cyano-6-methyl-2,3,4,5-tetrahydro-2-pyridinone; 1-(2-Chloro-6-fluorobenzyl)-5-cyano-6-methyl-2-oxo-1,2,3,4-tetrahydropyridine; 2(1H)-Pyridinone, 1-[(2-chloro-6-fluorophenyl)methyl]-5-cyano-3,4-dihydro-6-methyl-; 338748-74-6; CAS 338748-74-6
EINECS	Contact for details

Quality Control

Our production of 1-(2-Chloro-6-Fluorobenzyl)-5-Cyano-6-Methyl-1,2,3,4-Tetrahydropyridin-2-One adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.