Description

n-(5-Iodo-2-Pyridinyl)-3-(Trifluoromethyl)Benzenecarboxamide CAS NO 338401-02-8 is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyridine and trifluoromethylbenzene structure. This compound is critical for medicinal chemistry research and development, offering a versatile building block for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization.
• Kinase Inhibitor Synthesis: A crucial component in the synthesis of targeted kinase inhibitors for oncology applications.
• Labeled Compound Precursor: The iodine moiety provides a potential site for radiolabeling (e.g., with I-125) for use in diagnostic imaging or biochemical assays.
• Chemical Biology Probes: Employed in the creation of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Details
Product Name	n-(5-Iodo-2-Pyridinyl)-3-(Trifluoromethyl)Benzenecarboxamide
CAS No.	338401-02-8
Molecular Formula	C13H8F3IN2O
Molecular Weight	392.12 g/mol
Synonyms	3'-(Trifluoromethyl)-5-iodo-2-pyridinecarboxanilide; N-(5-Iodo-2-pyridinyl)-3-(trifluoromethyl)benzamide; 5-Iodo-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide; 338401-02-8; Benzamide, N-(5-iodo-2-pyridinyl)-3-(trifluoromethyl)-; 3-Trifluoromethyl-N-(5-iodopyridin-2-yl)benzamide
EINECS	Contact for details

Quality Control

Our n-(5-Iodo-2-Pyridinyl)-3-(Trifluoromethyl)Benzenecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.