Description

3-(4-Methylphenyl)-2-[(2-Oxo-2-Phenylethyl)Sulfanyl]-5,6-Dihydrospiro(Benzo[H]Quinazoline-5,1'-Cyclopentane)-4(3H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic quinazoline structure. This compound is of significant value for research and development in medicinal chemistry, particularly for synthesizing novel drug candidates targeting specific biological pathways. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, especially those exploring spirocyclic and quinazoline-based scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes within academic and industrial R&D settings.
• Chemical Biology Probe Development: Serves as a precursor for creating specialized probes to study enzyme function or protein interactions in biological systems.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke compounds for client projects.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3-(4-Methylphenyl)-2-[(2-Oxo-2-Phenylethyl)Sulfanyl]-5,6-Dihydrospiro(Benzo[H]Quinazoline-5,1'-Cyclopentane)-4(3H)-One
CAS No.	337495-81-5
Molecular Formula	C31H28N2O2S
Molecular Weight	492.63 g/mol
Synonyms	3-(p-Tolyl)-2-[(2-oxo-2-phenylethyl)thio]-5,6-dihydrospiro[benzo[h]quinazoline-5,1'-cyclopentane]-4(3H)-one; Spiro[cyclopentane-1,5'-[5,6]dihydrobenzo[h]quinazoline]-4'(3'H)-one, 2'-[[(2-oxo-2-phenylethyl)thio]-3'-(4-methylphenyl)-; CAS 337495-81-5; 3-(4-Methylphenyl)-2-[(2-oxo-2-phenylethyl)thio]-5,6-dihydrospiro[benzo[h]quinazoline-5,1'-cyclopentane]-4(3H)-one; 3-(4-Methylphenyl)-2-[(2-oxo-2-phenylethyl)sulfanyl]-5,6-dihydrospiro[benzo[h]quinazoline-5,1'-cyclopentane]-4(3H)-one
EINECS	Contact for details

Quality Control

Our 3-(4-Methylphenyl)-2-[(2-Oxo-2-Phenylethyl)Sulfanyl]-5,6-Dihydrospiro(Benzo[H]Quinazoline-5,1'-Cyclopentane)-4(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.