Description

Methyl 5-(tert-Butyldimethylsilyloxymethyl-2,6-Diisopropyl-4-(4-Fluorophenyl)-Pyridine-3-Carboxylate is a high-value, multi-functional pyridine derivative featuring a fluorophenyl group and a protected hydroxymethyl side chain. This compound matters as a critical advanced pharmaceutical intermediate (API), prized for its structural complexity which enables the synthesis of targeted bioactive molecules. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and agrochemical sectors for constructing novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Research: Serves as a precursor for developing new generation pesticides and herbicides, leveraging the fluorophenyl moiety for enhanced biological activity.
• Chemical Synthesis Reagent: Used in organic synthesis as a protected intermediate, allowing for selective reactions at other sites on the pyridine core.
• Material Science Research: Potential monomer or precursor for creating specialized polymers and ligands for metal-organic frameworks (MOFs) or catalysts.
• Academic & Contract Research: Essential for medicinal chemistry programs in academic institutions and contract research organizations (CROs) exploring structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	Methyl 5-(tert-Butyldimethylsilyloxymethyl-2,6-Diisopropyl-4-(4-Fluorophenyl)-Pyridine-3-Carboxylate
CAS No.	334933-44-7
Molecular Formula	C27H40FNO3Si
Molecular Weight	473.70 g/mol
Synonyms	Methyl 5-((tert-butyldimethylsilyloxy)methyl)-2,6-diisopropyl-4-(4-fluorophenyl)nicotinate; 3-Pyridinecarboxylic acid, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,6-bis(1-methylethyl)-4-(4-fluorophenyl)-, methyl ester; Methyl 5-(TBDMS-oxymethyl)-2,6-diisopropyl-4-(4-fluorophenyl)pyridine-3-carboxylate; 334933-44-7; TBDMS-protected pyridine ester; 4-(4-Fluorophenyl)-2,6-diisopropyl-5-((tert-butyldimethylsilyloxy)methyl)nicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 5-(tert-Butyldimethylsilyloxymethyl-2,6-Diisopropyl-4-(4-Fluorophenyl)-Pyridine-3-Carboxylate adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.