Description

Methyl 3-Bromo-5-Fluorobenzoate CAS NO 334792-52-8 is a high-purity fluorinated aromatic ester building block essential for advanced organic synthesis. This compound is valued for its precise molecular architecture, enabling the introduction of both bromo and fluoro substituents in a single, versatile reagent. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic cores in electronic and display materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Functional Group Transformation: The ester group can be hydrolyzed to the corresponding acid or reduced to the alcohol, providing access to further derivatives.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	Methyl 3-Bromo-5-Fluorobenzoate
CAS No.	334792-52-8
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	3-Bromo-5-fluorobenzoic acid methyl ester; Methyl 3-bromo-5-fluorobenzoate; Benzoic acid, 3-bromo-5-fluoro-, methyl ester; 5-Fluoro-3-bromobenzoic acid methyl ester; Methyl 5-fluoro-3-bromobenzoate; 334792-52-8; 3-Bromo-5-fluorobenzoic acid, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Bromo-5-Fluorobenzoate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot undergoes comprehensive analysis using advanced techniques including HPLC, GC, and NMR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.