Description

[2-(3,5-Difluorophenyl)-2-Hydroxyethyl]-Carbamic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific difluorophenyl and carbamate-protected amino alcohol structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and process optimization.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other specialized therapeutic areas.
• Protease Inhibitor Research: Serves as a precursor in the development of protease inhibitor libraries for antiviral and anticancer drug discovery programs.
• Chiral Synthesis: Utilized in asymmetric synthesis routes due to its chiral center, enabling the production of enantiomerically pure compounds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization processes to improve pharmacokinetic properties.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	[2-(3,5-Difluorophenyl)-2-Hydroxyethyl]-Carbamic Acid 1,1-Dimethylethyl Ester
CAS No.	333388-01-5
Molecular Formula	C13H17F2NO3
Molecular Weight	273.28 g/mol
Synonyms	tert-Butyl N-[2-(3,5-difluorophenyl)-2-hydroxyethyl]carbamate; (2-(3,5-Difluorophenyl)-2-hydroxyethyl)carbamic acid tert-butyl ester; BOC-3,5-Difluorophenylethanolamine; N-Boc-2-Amino-1-(3,5-difluorophenyl)ethanol; 1,1-Dimethylethyl N-[2-(3,5-difluorophenyl)-2-hydroxyethyl]carbamate; N-(tert-Butoxycarbonyl)-2-amino-1-(3,5-difluorophenyl)ethanol
EINECS	Contact for details

Quality Control

Our production of [2-(3,5-Difluorophenyl)-2-Hydroxyethyl]-Carbamic Acid 1,1-Dimethylethyl Ester adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical R&D. All materials are characterized by modern analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.