Description

2-[(2-Phenylethyl)Sulfanyl]-5,6-Dihydrospiro(Benzo[H]Quinazoline-5,1'-Cyclohexane)-4(3H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic quinazoline structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique spirocyclic scaffold.
• Kinase Inhibitor Development: Serves as a core structure for the design and synthesis of potential kinase inhibitors for cancer therapy.
• CNS Drug Discovery: Employed in research programs aimed at developing new agents for neurological and psychiatric disorders.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D and scale-up activities.

Basic Information

Product Name	2-[(2-Phenylethyl)Sulfanyl]-5,6-Dihydrospiro(Benzo[H]Quinazoline-5,1'-Cyclohexane)-4(3H)-One
CAS No.	332145-39-8
Molecular Formula	C26H28N2OS
Molecular Weight	416.58 g/mol
Synonyms	2-[(2-Phenylethyl)thio]-5,6-dihydrospiro[benzo[h]quinazoline-5,1'-cyclohexan]-4(3H)-one; 2-(2-Phenylethylsulfanyl)-5,6-dihydrospiro[benzo[h]quinazoline-5,1'-cyclohexane]-4(3H)-one; Spiro[benzo[h]quinazoline-5,1'-cyclohexane]-4(3H)-one, 2-[(2-phenylethyl)thio]-5,6-dihydro-; CAS 332145-39-8
EINECS	Contact for details

Quality Control

Our 2-[(2-Phenylethyl)Sulfanyl]-5,6-Dihydrospiro(Benzo[H]Quinazoline-5,1'-Cyclohexane)-4(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.