Description

4-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Pyridin-2-Ylamine is a high-value, protected pyridine derivative, specifically an amine functionalized with a tert-butyldimethylsilyl (TBDMS) ether group. This compound serves as a crucial versatile synthetic intermediate and key building block in advanced organic synthesis, enabling the controlled introduction of the 2-aminopyridine moiety under mild conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and complex specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those containing complex heterocyclic structures like kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used as a building block for developing novel pesticides, herbicides, and fungicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, dyes, and advanced organic materials with specific electronic or photonic properties.
• Chemical Biology Probes: Utilized to create tagged or modified molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A key requested intermediate for custom synthesis projects requiring protected amine functionality on a pyridine scaffold.

Basic Information

Product Name	4-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Pyridin-2-Ylamine
CAS No.	329794-09-4
Molecular Formula	C₁₂H₂₂N₂OSi
Molecular Weight	238.40 g/mol
Synonyms	2-Amino-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]pyridine; 4-((tert-Butyldimethylsilyloxy)methyl)pyridin-2-amine; 2-Amino-4-((tert-butyldimethylsilyloxy)methyl)pyridine; 4-(TBDMS-oxymethyl)-2-aminopyridine; 4-[(tert-Butyldimethylsilyloxy)methyl]-2-pyridinamine; 4-((tert-Butyldimethylsilyloxy)methyl)-2-pyridinamine; 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-2-pyridinamine
EINECS	Contact for details

Quality Control

Our production of 4-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Pyridin-2-Ylamine adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.