Description

Lirimilast CAS NO 329306-27-6 is a potent and selective phosphodiesterase 4 (PDE4) inhibitor, representing a significant class of compounds in modern therapeutic development. Its primary value lies in its targeted anti-inflammatory and immunomodulatory activity, making it a critical intermediate and active pharmaceutical ingredient (API) for research and production. This compound is essential for pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) focused on developing novel treatments for inflammatory and autoimmune conditions.

Application

• Pharmaceutical API Synthesis: Serves as the core active ingredient in the development and commercial manufacturing of PDE4 inhibitor-based therapeutics.
• Anti-inflammatory Drug Research: A key compound for preclinical and clinical research targeting chronic inflammatory diseases such as chronic obstructive pulmonary disease (COPD), psoriasis, and atopic dermatitis.
• Immunology Studies: Used as a reference standard and tool compound in biochemical and cellular assays to study PDE4 enzyme activity and intracellular cAMP signaling pathways.
• Process Chemistry & Scale-up: Employed as a critical intermediate for process optimization, route scouting, and kilogram-scale production under GMP or non-GMP conditions.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control (HPLC, LC-MS) of related pharmaceutical products.

Basic Information

Product Name	Lirimilast
CAS No.	329306-27-6
Molecular Formula	C₁₉H₁₇Cl₂N₃O₄
Molecular Weight	422.26 g/mol
Synonyms	Lirimilast; 4-[(3,5-Dichloro-4-pyridinyl)oxy]-3-methoxy-N-[1-(4-morpholinyl)carbonyl]-1H-indole-1-carboxamide; BAY 19-8004; E 6006; UNII-8K8L0VQ8VJ; PDE4 Inhibitor Lirimilast; 1-[[4-[(3,5-Dichloro-4-pyridinyl)oxy]-3-methoxy-1H-indol-1-yl]carbonyl]-4-morpholinecarboxamide
EINECS	Contact for details

Quality Control

Our Lirimilast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and rigorous control of impurities (related substances, residual solvents, heavy metals). A Certificate of Analysis (COA) detailing all test results against predefined specifications is provided with every shipment. We support development and commercial projects with material suitable for research use, non-GMP, or GMP applications, subject to specific grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require desiccant to protect from moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.