Description

2-(Prop-2-Yn-1-Ylsulfanyl)-3H-Spiro[Benzo[H]Quinazoline-5,1'-Cyclohexan]-4(6H)-One is a sophisticated spirocyclic quinazolinone derivative featuring a propargyl thioether functional group. This unique molecular architecture makes it a high-value synthetic intermediate and a promising scaffold for advanced research and development. It is primarily sought after by pharmaceutical R&D teams and specialty chemical manufacturers engaged in developing novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly for targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in high-throughput screening for new therapeutic agents.
• Chemical Biology Probe Development: The alkyne group enables "click chemistry" applications for labeling, bioconjugation, and studying biological pathways.
• Organic Synthesis: Acts as a versatile precursor for further chemical modifications, leveraging both the spirocyclic core and the reactive thioether-alkyne moiety.
• Agrochemical Research: Investigated as a potential intermediate for developing new crop protection agents with novel modes of action.

Basic Information

Product Name	2-(Prop-2-Yn-1-Ylsulfanyl)-3H-Spiro[Benzo[H]Quinazoline-5,1'-Cyclohexan]-4(6H)-One
CAS No.	328070-56-0
Molecular Formula	C21H20N2OS
Molecular Weight	348.46 g/mol
Synonyms	2-(Prop-2-yn-1-ylsulfanyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclohexan]-4(6H)-one; 2-(Prop-2-ynylthio)-3H-spiro[benzo[h]quinazoline-5,1'-cyclohexane]-4(6H)-one; 328070-56-0; Spiro[benzo[h]quinazoline-5,1'-cyclohexane]-4(6H)-one, 2-(2-propynylthio)-3H-; 2-(Prop-2-yn-1-ylthio)-3H-spiro[benzo[h]quinazoline-5,1'-cyclohexan]-4(6H)-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.