Description

Methyl 4-Oxo-4-{[4-(1-Pyrrolidinylsulfonyl)Phenyl]Amino}Butanoate is a high-purity, synthetic organic compound featuring a unique molecular scaffold combining a pyrrolidine sulfonamide moiety with a γ-keto ester. This structure makes it a valuable and versatile pharmaceutical intermediate and research chemical for medicinal chemistry programs. It is primarily utilized by R&D scientists and process chemists in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents, particularly those targeting enzyme inhibition.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block for the development of potential drug candidates, especially protease inhibitors and kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable functional groups (ketone, ester, sulfonamide).
• Chemical Biology Probes: Can be utilized to develop activity-based probes for studying enzyme function and mechanism in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from milligram to kilogram.
• Reference Standard: Sourced for analytical purposes as a high-purity reference material in quality control laboratories.

Basic Information

Product Name	Methyl 4-Oxo-4-{[4-(1-Pyrrolidinylsulfonyl)Phenyl]Amino}Butanoate
CAS No.	327067-58-3
Molecular Formula	C15H20N2O5S
Molecular Weight	340.40 g/mol
Synonyms	Methyl 4-((4-(pyrrolidine-1-sulfonyl)phenyl)amino)-4-oxobutanoate; 4-Oxo-4-{[4-(1-pyrrolidinylsulfonyl)phenyl]amino}butanoic Acid Methyl Ester; Butanoic acid, 4-[[4-(1-pyrrolidinylsulfonyl)phenyl]amino]-4-oxo-, methyl ester; Methyl γ-keto-4-(N-(4-(pyrrolidine-1-sulfonyl)phenyl))butyramide
EINECS	Contact for details

Quality Control

Every batch of our Methyl 4-Oxo-4-{[4-(1-Pyrrolidinylsulfonyl)Phenyl]Amino}Butanoate is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments for non-clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.