Description

2-Iodo-4-Trifluoromethyl-Pyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining an iodine substituent with a trifluoromethyl group on the pyridine ring, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for creating drug candidates with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group often contributes to improved biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) due to the reactive iodo substituent, enabling rapid diversification of molecular scaffolds.
• Ligand and Catalyst Development: Utilized to synthesize novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Item	Detail
Product Name	2-Iodo-4-Trifluoromethyl-Pyridine
CAS No.	326894-74-0
Molecular Formula	C6H3F3IN
Molecular Weight	288.99 g/mol
Synonyms	4-(Trifluoromethyl)-2-iodopyridine; 2-Iodo-4-(trifluoromethyl)pyridine; 2-Iodo-α,α,α-trifluoro-picoline; 2-Iodo-4-trifluoromethylpyridine; 4-Trifluoromethyl-2-iodopyridine; Pyridine, 2-iodo-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Iodo-4-Trifluoromethyl-Pyridine is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.