Description

6-[[2-(tert-Butyldimethylsilyloxy)Ethyl]Methylamino]Pyridin-3-Ol CAS NO 326496-02-0 is a high-purity, advanced pharmaceutical intermediate featuring a protected hydroxyl group and a tertiary amine functionality. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in drug discovery and development programs targeting neurological and metabolic disorders. It is primarily utilized by research institutions, custom synthesis laboratories, and pharmaceutical manufacturers requiring reliable, high-quality building blocks for complex organic synthesis.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of novel therapeutic agents, especially in central nervous system (CNS) and anti-diabetic drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile reactive sites for further functionalization.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the development and scale-up of proprietary compounds.
• Process Chemistry Development: Acts as a standard or starting material for developing robust and scalable synthetic routes in pilot plants and commercial manufacturing.
• Bioconjugation and Probe Development: The reactive amine and protected alcohol groups make it suitable for creating labeled compounds or molecular probes for biochemical assays.

Basic Information

Product Name	6-[[2-(tert-Butyldimethylsilyloxy)Ethyl]Methylamino]Pyridin-3-Ol
CAS No.	326496-02-0
Molecular Formula	C14H26N2O2Si
Molecular Weight	282.46 g/mol
Synonyms	6-[[2-[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethyl]methylamino]-3-pyridinol; 6-[(2-((tert-Butyldimethylsilyl)oxy)ethyl)(methyl)amino]pyridin-3-ol; 3-Hydroxy-6-[(2-((tert-butyldimethylsilyl)oxy)ethyl)(methyl)amino]pyridine; 6-[(2-(tert-Butyldimethylsilanyloxy)ethyl)-methyl-amino]-pyridin-3-ol; 326496-02-0; TBDMS-protected pyridinol derivative
EINECS	Contact for details

Quality Control

Our production of 6-[[2-(tert-Butyldimethylsilyloxy)Ethyl]Methylamino]Pyridin-3-Ol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert gas purging to maintain product stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.