Description

Pyridine, 2-Bromo-5-(Pentamethyldisilanyl)- (9Ci) is a specialized organosilicon-substituted pyridine derivative, serving as a valuable synthon in advanced organic and organometallic synthesis. This compound matters for its unique reactivity profile, combining the halogenated pyridine core with a silyl-protecting group, enabling precise functionalization in complex molecule construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the bromo and silyl groups allow for strategic coupling and deprotection steps.
• Ligand Precursor in Catalysis: Serves as a precursor for the development of sophisticated nitrogen-containing ligands used in transition metal catalysis for asymmetric synthesis.
• Materials Science Research: Employed in the creation of organic semiconductors, liquid crystals, or metal-organic frameworks (MOFs) due to its modifiable aromatic system and silicon moiety.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form biaryl or extended π-systems.
• Protecting Group Strategy: The pentamethyldisilanyl group can act as a protecting group for specific positions on the pyridine ring during multi-step synthetic sequences.

Basic Information

Product Name	Pyridine, 2-Bromo-5-(Pentamethyldisilanyl)- (9Ci)
CAS No.	325958-98-3
Molecular Formula	C12H20BrNSi2
Molecular Weight	314.37 g/mol
Synonyms	2-Bromo-5-(pentamethyldisilanyl)pyridine; 5-(Disilylmethyl)-2-bromopyridine; 2-Bromo-5-((trimethylsilyl)methyl)pyridine (related); Bromo(pentamethyldisilanyl)pyridine; Pyridine, bromo-(pentamethyldisilanyl)-; CAS 325958-98-3
EINECS	Contact for details

Quality Control

Our Pyridine, 2-Bromo-5-(Pentamethyldisilanyl)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed in a dry inert atmosphere to maximize shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.