Description

2-Bromo-5-Trimethylsilylpyridine is a versatile organosilicon building block and halogenated heterocyclic compound. This chemical is valued for its dual functionality, where the bromine atom serves as a site for cross-coupling reactions and the trimethylsilyl group offers protection and directs further functionalization. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those containing functionalized pyridine cores for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the pyridine moiety is a critical bioactive component.
• Material Science Research: Serves as a building block for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its ability to modify electronic properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl and other conjugated systems.
• Protecting Group Strategy: The trimethylsilyl group can be used as a temporary protecting group for the pyridine nitrogen or removed to reveal another reactive site for further synthesis.
• Ligand Synthesis: Employed in the preparation of specialized nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2-Bromo-5-Trimethylsilylpyridine
CAS No.	325958-97-2
Molecular Formula	C8H12BrNSi
Molecular Weight	230.18 g/mol
Synonyms	5-(Trimethylsilyl)-2-bromopyridine; 2-Bromo-5-(trimethylsilyl)pyridine; Pyridine, 2-bromo-5-(trimethylsilyl)-; 2-Bromo-5-pyridyltrimethylsilane; 2-Bromo-5-TMS-pyridine; 2-Br-5-TMSPy; (5-Bromo-2-pyridyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Trimethylsilylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.