Description

Indiplon is a non-benzodiazepine sedative-hypnotic agent belonging to the pyrazolopyrimidine class, primarily developed for the treatment of insomnia. Its mechanism of action involves selective binding to the GABAA receptor complex, which promotes sleep onset and maintenance with a favorable safety profile. This compound is of significant interest to pharmaceutical R&D departments and fine chemical manufacturers engaged in developing and producing advanced neuroactive therapeutic agents.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in sedative and hypnotic formulations for insomnia treatment.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Research & Development: Critical material for preclinical and clinical studies investigating sleep disorders and GABAergic pharmacology.
• Process Chemistry: Used as a key intermediate or final product in the synthesis and scale-up of novel neuropharmaceutical compounds.
• Formulation Development: Employed in the development of various dosage forms, including tablets and capsules, to optimize bioavailability and stability.

Basic Information

Product Name	Indiplon
CAS No.	325715-02-4
Molecular Formula	C22H19FN6O
Molecular Weight	402.43 g/mol
Synonyms	NBI-34060; Indiplon (USAN); 3-(5-Fluoro-2-pyridinyl)-N-[(3S)-2-oxo-1-phenyl-3-pyrrolidinyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide; (S)-3-(5-Fluoropyridin-2-yl)-N-(2-oxo-1-phenyl-3-pyrrolidinyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide; 1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 3-(5-fluoro-2-pyridinyl)-N-[(3S)-2-oxo-1-phenyl-3-pyrrolidinyl]-
EINECS	Contact for details

Quality Control

Our Indiplon is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity testing, ensuring reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.