Description

Carbamic Acid, [(1R,2S)-2-Hydroxy-1-Methyl-4-Pentenyl]-, 1,1-Dimethylethyl Ester is a high-purity, chiral carbamate derivative of significant interest in advanced organic synthesis. This compound serves as a critical protected intermediate for constructing complex molecules, offering precise stereochemical control. It is primarily sought by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel therapeutic agents, particularly in oncology and antiviral research.
• Peptidomimetics Synthesis: Used to introduce protected amino alcohol functionalities into peptide analogs and protease inhibitors.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts.
• Natural Product Synthesis: Intermediate in the total synthesis of complex natural products with biological activity.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides a stable, acid-labile protecting group for amines in multi-step syntheses.
• Chemical Biology Probes: Utilized in the development of labeled compounds and molecular probes for biochemical studies.

Basic Information

Product Name	Carbamic Acid, [(1R,2S)-2-Hydroxy-1-Methyl-4-Pentenyl]-, 1,1-Dimethylethyl Ester
CAS No.	324752-72-9
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	(1R,2S)-2-Hydroxy-1-methyl-4-penten-1-yl carbamic acid tert-butyl ester; tert-Butyl N-[(1R,2S)-2-hydroxy-1-methyl-4-pentenyl]carbamate; (1R,2S)-Boc-Amino Alcohol Derivative; Boc-L-isoleucinal-derived amino alcohol carbamate; (1R,2S)-1-(Boc-amino)-2-hydroxy-3-methyl-4-pentene; (2S,3R)-3-Hydroxy-2-methyl-4-penten-1-yl-carbamic acid tert-butyl ester; Chiral Boc-protected Amino Pentenol
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through advanced analytical techniques including HPLC, chiral GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC/GC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.