Description

Dispiro[2.0.2.1]Heptane-1-Methanol, 7,7-Difluoro-, (1R,3R)- (9Ci) is a high-value, chiral fluorinated building block characterized by its unique spirocyclic and strained bicyclic architecture. This compound matters as a sophisticated intermediate for advanced pharmaceutical and agrochemical research, where its rigid, three-dimensional structure and fluorine atoms are leveraged to modulate the biological activity, metabolic stability, and physicochemical properties of target molecules. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel small-molecule drugs, especially those targeting neurological disorders.
• Agrochemical Research: Used in the synthesis of advanced pesticides and herbicides, where the fluorine atoms enhance lipophilicity and membrane permeability.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential building block for specialty polymers and advanced organic materials requiring unique steric and electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex target molecules.

Basic Information

Product Name	Dispiro[2.0.2.1]Heptane-1-Methanol, 7,7-Difluoro-, (1R,3R)- (9Ci)
CAS No.	321857-21-0
Molecular Formula	C8H10F2O
Molecular Weight	160.16 g/mol
Synonyms	(1R,3R)-7,7-Difluoro-1-(hydroxymethyl)dispiro[2.0.2.1]heptane; (1R,3R)-7,7-Difluorodispiro[2.0.2.1]heptane-1-methanol; 7,7-Difluorodispiro[2.0.2.1]heptane-1-methanol, (1R,3R)-rel-; Dispiro[2.0.2.1]heptane-1-methanol, 7,7-difluoro-, (1R,3R)-; (1R,3R)-7,7-Difluoro-dispiro[2.0.2.1]heptanyl-1-methanol; Chiral Difluorinated Spiroheptane Methanol; (1R,3R)-enantiomer of CAS 321857-21-0.
EINECS	Contact for details

Quality Control

Our Dispiro[2.0.2.1]Heptane-1-Methanol, 7,7-Difluoro-, (1R,3R)- (9Ci) is manufactured under strict quality control protocols to ensure high chemical and chiral purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC/NMR), enantiomeric excess (by chiral HPLC), and impurity profiles. We adhere to cGMP principles where applicable to support pre-clinical and early-phase clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.