Description

α-Tosyl-(3,4-Difluorobenzyl)Isocyanide is a specialized organic building block featuring a reactive isocyanide group protected by a tosyl moiety and a difluorobenzyl substituent. This compound is valued for its role as a key intermediate in multi-component reactions, enabling the efficient synthesis of complex heterocyclic scaffolds and pharmacophores. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and advanced material synthesis programs.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of novel drug candidates, particularly for constructing nitrogen-containing heterocycles via Ugi and Passerini reactions.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging the difluorobenzyl group for enhanced biological activity and metabolic stability.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioorthogonal labeling and activity-based protein profiling (ABPP) due to the reactive isocyanide functionality.
• Material Science: Employed in the creation of functional polymers and advanced organic frameworks with tailored properties.
• Academic & Contract Research: Essential for methodological development in organic synthesis and catalysis within university and CRO laboratories.

Basic Information

Product Name	α-Tosyl-(3,4-Difluorobenzyl)Isocyanide
CAS No.	321345-37-3
Molecular Formula	C15H11F2NO2S
Molecular Weight	307.32 g/mol
Synonyms	N-[(3,4-Difluorophenyl)methyl]-N-(4-methylphenyl)sulfonylmethanimidoyl cyanide; 1-Isocyano-1-tosyl-2-(3,4-difluorophenyl)ethane; 2-(3,4-Difluorophenyl)-1-isocyano-1-tosylethane; TosMIC-(3,4-Difluorobenzyl) Derivative; α-Tosyl-3,4-difluorobenzyl isocyanide; (3,4-Difluorobenzyl)(tosylmethyl) isocyanide; TOS-3,4-Difluorobenzyl-NC
EINECS	Contact for details

Quality Control

Our α-Tosyl-(3,4-Difluorobenzyl)Isocyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and custom purity grades or analytical packages can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.