Description

[1-(3-Fluorophenyl)-1-Tosyl]Methyl Isocyanide is a specialized organic building block featuring a unique combination of a fluorinated phenyl ring, a tosyl protecting group, and a reactive isocyanide functional group. This compound matters for its versatility as a key intermediate in the synthesis of complex heterocycles and pharmaceuticals, particularly in multicomponent reactions like the Ugi and Passerini reactions. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Research: Used in the development of new active ingredients with enhanced properties due to the fluorine substituent.
• Heterocyclic Chemistry: Serves as a key reactant in multicomponent reactions (MCRs) to efficiently construct complex nitrogen-containing heterocycles.
• Chemical Biology & Probe Development: Utilized in the creation of isocyanide-based chemical probes for studying biological pathways and protein interactions.
• Material Science: Potential precursor for functionalized polymers or surface coatings with specific electronic properties.
• Academic & Contract Research: Essential for methodological development and discovery chemistry in university and CRO laboratories.

Basic Information

Product Name	[1-(3-Fluorophenyl)-1-Tosyl]Methyl Isocyanide
CAS No.	321345-36-2
Molecular Formula	C15H12FNO2S
Molecular Weight	289.32 g/mol
Synonyms	1-[(4-Methylphenyl)sulfonyl]-1-(3-fluorophenyl)methanimidoyl cyanide; 1-Tosyl-1-(3-fluorophenyl)methyl isocyanide; 3-Fluoro-α-tosylbenzyl isocyanide; (3-Fluorophenyl)(tosyl)methyl isocyanide; 1-(3-Fluorophenyl)-1-(p-tolylsulfonyl)methyl isocyanide; 1-(3-Fluorophenyl)-1-(4-methylphenylsulfonyl)methyl isocyanide; 1-(3-Fluorophenyl)-1-(p-toluenesulfonyl)methyl isocyanide
EINECS	Contact for details

Quality Control

Our [1-(3-Fluorophenyl)-1-Tosyl]Methyl Isocyanide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term stability. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.