Description

[1-(3-Chlorophenyl)-1-Tosyl]Methyl Isocyanide is a specialized organic building block featuring a unique isocyanide functional group. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, particularly in multicomponent reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures. Its specific structure makes it a critical reagent for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the creation of new pesticides and herbicides, leveraging its reactivity to form heterocyclic cores common in active ingredients.
• Material Science: Employed in the synthesis of specialized polymers and functional organic materials where the isocyanide group enables unique polymerization pathways.
• Academic & R&D: Serves as a crucial reagent in methodological chemistry research, particularly in Ugi-type and other isocyanide-based multicomponent reactions (MCRs).
• Chemical Library Synthesis: Utilized in combinatorial chemistry for the rapid generation of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	[1-(3-Chlorophenyl)-1-Tosyl]Methyl Isocyanide
CAS No.	321345-35-1
Molecular Formula	C15H12ClNO2S
Molecular Weight	305.78 g/mol
Synonyms	1-Isocyano-1-(3-chlorophenyl)-1-tosylethane; (3-Chlorophenyl)(tosyl)methyl isocyanide; [1-(3-Chlorophenyl)-1-(p-tolylsulfonyl)]methyl isocyanide; Tosyl(3-chlorophenyl)methyl isocyanide; 1-(3-Chlorophenyl)-1-(4-methylphenylsulfonyl)methane isocyanide; 3-Chloro-α-isocyano-p-tolylsulfonyltoluene
EINECS	Contact for details

Quality Control

Our [1-(3-Chlorophenyl)-1-Tosyl]Methyl Isocyanide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.