Description

1-Benzothiophen-3-Yl Isocyanate is a versatile and highly reactive aromatic isocyanate building block, essential for the synthesis of complex heterocyclic compounds. Its core value lies in enabling the formation of urea and carbamate linkages, which are critical for developing advanced materials and active pharmaceutical ingredients. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for creating novel molecules with targeted properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging the benzothiophene scaffold.
• Polymer Modification: Serves as a reactive monomer or cross-linking agent for producing specialty polyurethanes and polyurea coatings with enhanced performance characteristics.
• Material Science Research: Employed in the development of advanced organic electronic materials, such as semiconductors or charge-transport layers.
• Chemical Biology Probes: Useful for labeling biomolecules or creating activity-based probes for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs serving the life sciences sector.

Basic Information

Product Name	1-Benzothiophen-3-Yl Isocyanate
CAS No.	321309-37-9
Molecular Formula	C9H5NOS
Molecular Weight	175.21 g/mol
Synonyms	3-Isocyanatobenzothiophene; 1-Benzothiophene-3-isocyanate; Benzo[b]thiophen-3-yl isocyanate; 3-Benzothienyl isocyanate; 1-Benzothiophen-3-yl isocyanate; 3-Isocyanato-1-benzothiophene; Benzothiophene-3-isocyanate
EINECS	Contact for details

Quality Control

Our 1-Benzothiophen-3-Yl Isocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade material, ensuring traceability and compliance with global regulatory expectations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.