Description

1-Piperidinecarboxylic Acid, 3-[[(Phenylmethoxy)Carbonyl]Amino]-, 1,1-Dimethylethyl Ester, (3R)- is a high-purity, chiral piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for its stereochemical integrity and functional group compatibility.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, including protease inhibitors and other small molecule drugs.
• Peptidomimetic Chemistry: Used in the synthesis of peptidomimetics and constrained peptides to modulate biological activity and improve metabolic stability.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced crop protection agents with specific stereochemical requirements.
• Catalyst and Ligand Development: Employed in the design and synthesis of novel chiral catalysts and ligands for asymmetric synthesis.
• Chemical Biology Research: Utilized as a molecular probe or scaffold in medicinal chemistry and chemical biology studies.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects requiring high stereochemical purity and reliable supply.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 3-[[(Phenylmethoxy)Carbonyl]Amino]-, 1,1-Dimethylethyl Ester, (3R)-
CAS No.	320580-76-5
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	(3R)-3-[(Benzyloxycarbonyl)amino]-1-piperidinecarboxylic acid tert-butyl ester; tert-Butyl (3R)-3-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate; (R)-N-Cbz-3-Aminopiperidine-1-carboxylic acid tert-butyl ester; (R)-1-Boc-3-N-Cbz-aminopiperidine; (R)-3-[(Cbz-Amino)]-1-Boc-piperidine; (R)-1-N-Boc-3-N-Cbz-1,3-diaminopiperidine; Boc-(R)-3-CbzNH-piperidine; (3R)-1-(tert-Butoxycarbonyl)-3-{[(benzyloxy)carbonyl]amino}piperidine
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and manufacturing processes. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with each shipment. We support compliance with cGMP and ISO standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is moisture-sensitive; keep the container tightly sealed under inert atmosphere if necessary to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.