Description

2-Thiopheneacetic Acid, α-Hydroxy-α-2-Thienyl-, (3R)-1-Azabicyclo[2.2.2]Oct-3-Yl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents targeting the central nervous system. Pharmaceutical R&D and manufacturing organizations need this precise chemical to ensure the integrity and efficacy of their final drug products.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug molecules, especially those with neurological activity.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key chiral building block for constructing novel APIs, leveraging its (3R)-1-azabicyclo[2.2.2]oct-3-yl ester moiety.
• Neurological Research Compounds: Used in medicinal chemistry research for developing new candidates targeting nicotinic acetylcholine receptors or other CNS pathways.
• Process Chemistry & Scale-Up: Employed in process optimization and kilogram-scale production for clinical trial material and commercial manufacturing.
• Asymmetric Synthesis: Utilized in stereoselective synthesis due to its defined chiral center, contributing to the production of enantiomerically pure substances.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for custom synthesis projects.

Basic Information

Product Name	2-Thiopheneacetic Acid, α-Hydroxy-α-2-Thienyl-, (3R)-1-Azabicyclo[2.2.2]Oct-3-Yl Ester
CAS No.	320347-97-5
Molecular Formula	C15H19NO3S
Molecular Weight	293.38 g/mol
Synonyms	(R)-3-Quinuclidinyl 2-hydroxy-2-(thiophen-2-yl)acetate; (3R)-1-Azabicyclo[2.2.2]oct-3-yl 2-hydroxy-2-(thiophen-2-yl)acetate; 2-Hydroxy-2-(2-thienyl)acetic Acid (3R)-1-Azabicyclo[2.2.2]oct-3-yl Ester; (R)-Quinuclidin-3-yl 2-hydroxy-2-(thiophen-2-yl)acetate; A key intermediate for ABT-594 analogs; Troparil derivative intermediate; Tropane alkaloid synthetic intermediate
EINECS	Contact for details

Quality Control

Our 2-Thiopheneacetic Acid, α-Hydroxy-α-2-Thienyl-, (3R)-1-Azabicyclo[2.2.2]Oct-3-Yl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent pharmaceutical intermediate standards. Certificates of Analysis (COA) with full traceability are provided, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.