Description

Methyl 4-(Trimethylsilyl)But-3-Ynoate is a high-value organosilicon building block featuring both a silyl-protected alkyne and a methyl ester functional group. This unique bifunctional structure makes it a versatile intermediate for constructing complex molecular architectures in advanced synthetic chemistry. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and materials science industries for applications such as click chemistry, cross-coupling reactions, and the synthesis of novel polymers or bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its alkyne moiety enables the introduction of specific bioactive structures.
• Click Chemistry Reagent: Serves as a protected alkyne component for Huisgen cycloaddition (copper-catalyzed azide-alkyne cycloaddition or CuAAC) reactions in bioconjugation and materials labeling.
• Materials Science & Polymer Chemistry: Employed as a monomer or co-monomer for creating specialty polymers, dendrimers, and silicon-containing advanced materials with tailored properties.
• Organic Synthesis Building Block: Facilitates the construction of complex natural products and organic molecules in academic and industrial research laboratories.
• Liquid Crystal & OLED Material Precursor: Used in the development of organic electronic materials due to its ability to incorporate rigid, conjugated structures.

Basic Information

Product Name	Methyl 4-(Trimethylsilyl)But-3-Ynoate
CAS No.	319919-26-1
Molecular Formula	C9H16O2Si
Molecular Weight	184.31 g/mol
Synonyms	Methyl 4-(trimethylsilyl)-3-butynoate; 3-Butynoic acid, 4-(trimethylsilyl)-, methyl ester; Methyl 4-(trimethylsilyl)but-3-ynoate; 4-(Trimethylsilyl)-3-butynoic acid methyl ester; TMS-Propargylic Ester; Methyl (trimethylsilyl)propiolate derivative
EINECS	Contact for details

Quality Control

Our Methyl 4-(Trimethylsilyl)But-3-Ynoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.