Description

Methyl (S)-(-)-3-(T-Butyldi-Me-Silyloxy) is a high-purity, chiral silyl-protected intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for the stereoselective construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for producing active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral therapeutics.
• Asymmetric Synthesis: Used in stereocontrolled reactions to introduce the (S)-configured stereocenter into target molecules with high enantiomeric purity.
• Natural Product Synthesis: Serves as a protected alcohol precursor in the total synthesis of complex natural products with biological activity.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where specific stereochemistry is required for efficacy.
• Process Chemistry & Scale-Up: Utilized in the development and optimization of scalable manufacturing routes for chiral compounds under GMP-like conditions.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry, exploring new catalytic and protective group strategies.

Basic Information

Item	Details
Product Name	Methyl (S)-(-)-3-(T-Butyldi-Me-Silyloxy)
CAS No.	308103-47-1
Molecular Formula	C10H24O2Si
Molecular Weight	204.39 g/mol
Synonyms	(S)-Methyl 3-((tert-Butyldimethylsilyl)oxy); Methyl (S)-3-(tert-Butyldimethylsilyloxy); (S)-(-)-Methyl 3-(TBDMS-oxy); TBDMS-protected (S)-Methyl 3-hydroxy; (S)-Methyl 3-TBDMS ether; tert-Butyldimethylsilyl (S)-methyl 3-ether; (S)-3-[(tert-Butyldimethylsilyl)oxy]methyl
EINECS	Contact for details

Quality Control

Our Methyl (S)-(-)-3-(T-Butyldi-Me-Silyloxy) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity, meeting the stringent requirements of pharmaceutical R&D. We provide comprehensive Certificates of Analysis (COA) for each batch, detailing purity, chiral purity, and impurity profiles. Our quality system is designed to support regulatory filings, and we can supply material suitable for use under cGMP guidelines for non-clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.