Description

Methyl (S)-(-)-4-(tert-Butyldimethylsiloxy)-2-methylbutanoate is a high-purity chiral intermediate, a key building block in the synthesis of complex pharmaceutical molecules. Its defined stereochemistry is critical for producing enantiomerically pure active pharmaceutical ingredients (APIs) with the desired biological activity. This compound is essential for research and development chemists and process engineers in the pharmaceutical and fine chemical industries, particularly for projects involving prostaglandins, antiviral agents, and other chiral therapeutics.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of prostaglandin analogs and other bioactive molecules.
• Asymmetric Synthesis: Used as a starting material or intermediate in stereoselective reactions to construct complex molecular architectures.
• Process Chemistry: Serves as a key raw material in the scale-up and optimization of API manufacturing processes under GMP conditions.
• Research & Development: Employed in medicinal chemistry for the discovery and development of new chiral drug candidates.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals requiring high enantiomeric purity.

Basic Information

Item	Details
Product Name	Methyl (S)-(-)-4-(tert-Butyldimethylsiloxy)-2-methylbutanoate
CAS No.	307532-01-0
Molecular Formula	C13H28O3Si
Molecular Weight	260.45 g/mol
Synonyms	(S)-Methyl 4-((tert-Butyldimethylsilyl)oxy)-2-methylbutanoate; (S)-(-)-4-(tert-Butyldimethylsiloxy)-2-methylbutyric Acid Methyl Ester; Methyl (S)-4-(tert-Butyldimethylsilyloxy)-2-methylbutanoate; TBDMS-protected (S)-methyl 2-methyl-4-hydroxybutanoate; (S)-Methyl 2-methyl-4-((tert-butyldimethylsilyl)oxy)butanoate
EINECS	Contact for details

Quality Control

Our production of Methyl (S)-(-)-4-(tert-Butyldimethylsiloxy)-2-methylbutanoate adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (typically >98.0% by HPLC), enantiomeric excess (typically >99.0% ee), and impurity profiles. We support development and commercial projects with quality standards suitable for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.