Description

4'-(Bromomethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid Methyl Ester is a high-purity biphenyl derivative featuring a reactive bromomethyl group and a methyl ester functionality, making it a versatile and critical building block for advanced organic synthesis. Its primary value lies in its dual functionality, which enables its use as a key intermediate in the construction of complex molecular architectures, particularly in pharmaceutical and materials science research. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for drug discovery and fine chemical production.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds with biphenyl or substituted biphenyl cores.
• Ligand and Catalyst Synthesis: Used to construct sophisticated ligands for catalysis or as a building block for metal-organic frameworks (MOFs) and other functional materials.
• Agrochemical Research: Acts as an intermediate in the development of new herbicides, fungicides, and plant growth regulators.
• Liquid Crystal and OLED Materials: Employed in the synthesis of organic electronic materials, where the biphenyl unit contributes to desired photophysical and self-assembly properties.
• Cross-Coupling Reactions: The bromomethyl group is a reactive handle for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to introduce complex substituents.
• Polymer Chemistry: Functions as a monomer or chain extender in the production of specialty polymers with enhanced thermal or mechanical properties.

Basic Information

Item	Detail
Product Name	4'-(Bromomethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid Methyl Ester
CAS No.	306271-99-8
Molecular Formula	C16H15BrO2
Molecular Weight	319.20 g/mol
Synonyms	Methyl 4'-(bromomethyl)biphenyl-4-carboxylate; [1,1'-Biphenyl]-4-carboxylic acid, 4'-(bromomethyl)-, methyl ester; 4'-(Bromomethyl)biphenyl-4-carboxylic acid methyl ester; Methyl 4'-(bromomethyl)-[1,1'-biphenyl]-4-carboxylate; 4-Bromomethyl-4'-methoxycarbonylbiphenyl; Biphenyl-4-carboxylic acid, 4'-(bromomethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Every batch of 4'-(Bromomethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid Methyl Ester undergoes rigorous analytical testing to ensure it meets the high standards required for research and production. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods to verify identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance documentation for your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.