Description

5-Bromo-2',3',5',6'-Tetrahydrospiro[Indoline-3,4'-Pyran]-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic molecular architecture. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel bioactive molecules and active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates and novel chemical entities (NCEs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Building Block: Employed in the construction of complex heterocyclic systems and spirocyclic compounds for advanced material science.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for methodological development and the study of spirocyclic reaction mechanisms.

Basic Information

Product Name	5-Bromo-2',3',5',6'-Tetrahydrospiro[Indoline-3,4'-Pyran]-2-One
CAS No.	304876-31-1
Molecular Formula	C13H12BrNO2
Molecular Weight	294.14 g/mol
Synonyms	5-Bromospiro[indoline-3,4'-pyran]-2-one; 5-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one; 5-Bromo-2H-spiro[indole-3,4'-pyran]-2-one; 5-Bromospiro[indoline-3,4'-4H-pyran]-2-one; 5-Bromo-2,3-dihydrospiro[indole-3,4'-pyran]-2-one; 304876-31-1; Spiro[indoline-3,4'-pyran]-2-one, 5-bromo-2',3',5',6'-tetrahydro-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2',3',5',6'-Tetrahydrospiro[Indoline-3,4'-Pyran]-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.