Description

2',3',5',6'-Tetrahydrospiro[Indoline-3,4'-Pyran]-2-One is a sophisticated spirocyclic organic compound featuring a fused indoline and tetrahydropyran structure, serving as a valuable advanced intermediate in modern synthetic chemistry. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. Pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers need this high-purity building block to enable innovative synthesis pathways and product development.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic small molecules.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its spirocyclic scaffold to create compounds with unique biological activity and environmental profiles.
• Material Science: Serves as a precursor for organic electronic materials, liquid crystals, or advanced polymers where its rigid, three-dimensional structure can impart specific physical properties.
• Academic & R&D: Employed in university and institutional laboratories for methodological studies in asymmetric synthesis, spirocyclization reactions, and heterocyclic chemistry research.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	2',3',5',6'-Tetrahydrospiro[Indoline-3,4'-Pyran]-2-One
CAS No.	304876-29-7
Molecular Formula	C13H15NO2
Molecular Weight	217.26 g/mol
Synonyms	Spiro[indoline-3,4'-pyran]-2-one, 2',3',5',6'-tetrahydro-; 2',3',5',6'-Tetrahydrospiro[indoline-3,4'-pyran]-2-one; Tetrahydrospiro[indoline-3,4'-pyran]-2-one; 304876-29-7; Spiro[Indoline-3,4'-Pyran]-2-One, 2',3',5',6'-Tetrahydro-; 2H-Spiro[indole-3,4'-pyran]-2-one, 1',3',4',5'-tetrahydro-
EINECS	Contact for details

Quality Control

Our 2',3',5',6'-Tetrahydrospiro[Indoline-3,4'-Pyran]-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.