Description

Spiro[Cyclopentane-1,3'-[3H]Indol]-2'(1'H)-One,5'-Bromo- CAS NO 304876-16-2 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole scaffold. This compound is of significant value for its role as a critical building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the spirocyclic indole core.
• Process Chemistry Development: Employed in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the design and creation of molecular probes to study specific biological pathways and protein functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global clients.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Spiro[Cyclopentane-1,3'-[3H]Indol]-2'(1'H)-One,5'-Bromo-
CAS No.	304876-16-2
Molecular Formula	C₁₃H₁₂BrNO
Molecular Weight	278.15 g/mol
Synonyms	5'-Bromospiro[cyclopentane-1,3'-indolin]-2'-one; 5'-Bromo-1'H-spiro[cyclopentane-1,3'-indol]-2'-one; 5'-Bromospiro[indoline-3,1'-cyclopentan]-2-one; 5'-Bromo-2-oxospiro[cyclopentane-1,3'-indoline]; 304876-16-2; Spiro(cyclopentane-1,3'-(3H)indol)-2'(1'H)-one, 5'-bromo-
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopentane-1,3'-[3H]Indol]-2'(1'H)-One,5'-Bromo- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, residual solvents, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.