Description

5'-Bromospiro[Cyclohexane-1,3'-Indol]-2'(1'H)-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indole scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecular architectures. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel bioactive molecules, particularly for applications in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential ligand or linker component in the design of targeted protein degraders.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for investigating biological pathways and target validation.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis.
• Contract Research & Manufacturing (CRAM): Supplied to service organizations supporting outsourced drug discovery programs.

Basic Information

Product Name	5'-Bromospiro[Cyclohexane-1,3'-Indol]-2'(1'H)-One
CAS No.	304468-42-6
Molecular Formula	C14H16BrNO
Molecular Weight	294.19 g/mol
Synonyms	5'-Bromospiro[cyclohexane-1,3'-indolin]-2'-one; 2'(1'H)-Indolone, 5'-bromospiro[cyclohexane-1,3'-[3H]indol]-; 5'-Bromo-1'H-spiro[cyclohexane-1,3'-indol]-2'-one; 5'-Bromospiro(cyclohexane-1,3'-indolin)-2'-one; 5'-Bromo-spiro[cyclohexane-1,3'-indolin]-2'-one; 304468-42-6; Spiro[cyclohexane-1,3'-indole]-2'(1'H)-one, 5'-bromo-
EINECS	Contact for details

Quality Control

Our 5'-Bromospiro[Cyclohexane-1,3'-Indol]-2'(1'H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and mass spectrometry. We support our clients' regulatory needs with documentation suitable for research and development filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.