Description

(3Ar,6Ar)-6-((tert-Butyldiphenylsilyloxy)Methyl)-2,2-Dimethyl-3Ah-Cyclopenta[D][1,3]Dioxol-4(6Ah)-One is a sophisticated chiral building block and protected intermediate of significant value in advanced organic synthesis. Its structure, featuring a silyl-protected hydroxyl group and a dioxolane moiety, makes it a critical precursor for the stereoselective construction of complex molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of nucleoside analogs, prostaglandins, and other bioactive compounds requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially antiviral and anticancer nucleoside analogs.
• Asymmetric Synthesis: Utilized as a building block for constructing complex natural products and bioactive molecules with defined stereochemistry.
• Prostanoid Synthesis: Serves as a protected intermediate in the synthetic pathways for prostaglandins and related prostanoid compounds.
• Carbocyclic Nucleoside Preparation: Employed in the research and development of novel carbocyclic nucleoside derivatives with potential therapeutic applications.
• Fine Chemical Production: Used in custom synthesis and process development for high-value specialty chemicals.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	(3Ar,6Ar)-6-((tert-Butyldiphenylsilyloxy)Methyl)-2,2-Dimethyl-3Ah-Cyclopenta[D][1,3]Dioxol-4(6Ah)-One
CAS No.	303963-92-0
Molecular Formula	C27H34O4Si
Molecular Weight	450.65 g/mol
Synonyms	6-[(tert-Butyldiphenylsilyloxy)methyl]-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one; (3aR,6aR)-6-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]methyl]-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one; TBDPS-protected cyclopentadiene dioxolane derivative; Chiral TBDPS ether of cyclopentenone acetonide; CAS 303963-92-0
EINECS	Contact for details

Quality Control

Our (3Ar,6Ar)-6-((tert-Butyldiphenylsilyloxy)Methyl)-2,2-Dimethyl-3Ah-Cyclopenta[D][1,3]Dioxol-4(6Ah)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.