Description

Ethyl 6-Chloro-5-Cyano-2-Phenylnicotinate is a high-purity, multi-functional heterocyclic building block of significant commercial interest. This compound is valued for its role as a key synthetic intermediate in the development of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its pyridine core for biological activity.
• Material Science Research: Serves as a building block for creating functional organic materials, including ligands for catalysis and components for organic electronics.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the discovery of new chemical reactions.
• Custom Synthesis & Scale-Up: A starting material for contract manufacturing organizations (CMOs) engaged in custom synthesis projects from gram to multi-kilogram scale.

Basic Information

Product Name	Ethyl 6-Chloro-5-Cyano-2-Phenylnicotinate
CAS No.	303146-96-5
Molecular Formula	C15H11ClN2O2
Molecular Weight	286.71 g/mol
Synonyms	Ethyl 6-chloro-5-cyano-2-phenylpyridine-3-carboxylate; 2-Phenyl-6-chloro-5-cyano-3-pyridinecarboxylic acid ethyl ester; 6-Chloro-5-cyano-2-phenylnicotinic acid ethyl ester; 3-Pyridinecarboxylic acid, 6-chloro-5-cyano-2-phenyl-, ethyl ester; Ethyl 2-phenyl-6-chloro-5-cyanonicotinate; 303146-96-5; Ethyl 6-chloro-2-phenyl-5-cyanonicotinate
EINECS	Contact for details

Quality Control

Our Ethyl 6-Chloro-5-Cyano-2-Phenylnicotinate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or GMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.