Description

Methyl 5-Cyano-2-Methyl-6-(Propylamino)Nicotinate is a high-purity, functionalized nicotinate derivative serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique molecular scaffold, which is designed for the efficient construction of complex heterocyclic systems, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides that require specific pyridine-based pharmacophores.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating labeled compounds or molecular probes used in biochemical assay development and target identification.
• Material Science Precursor: Potential intermediate for the synthesis of functionalized ligands used in catalysis or for creating novel organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Product Name	Methyl 5-Cyano-2-Methyl-6-(Propylamino)Nicotinate
CAS No.	303146-91-0
Molecular Formula	C12H15N3O2
Molecular Weight	233.27 g/mol
Synonyms	5-Cyano-2-methyl-6-(propylamino)nicotinic acid methyl ester; Methyl 5-cyano-2-methyl-6-(propylamino)pyridine-3-carboxylate; 6-(Propylamino)-5-cyano-2-picolinic acid methyl ester; 3-Pyridinecarboxylic acid, 5-cyano-2-methyl-6-(propylamino)-, methyl ester; Propylamino-nicotinate derivative; PYN intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of Methyl 5-Cyano-2-Methyl-6-(Propylamino)Nicotinate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.